Immunoglobulin E—an Innocent Bystander in Host Defense?
نویسنده :
تاریخ انتشار : 1397/06/03
Discoveries of physiology often precede anatomy in immunology
research. Forty-five years before the discovery of IgE,
Prausnitz and Küstner found that allergy can be transferred by
sera from allergic patients in 1921 . Tested by erythemawheal
assays, this serum fraction was named Breagin. With
the advances in electrophoresis and ultracentrifugation between
the 1930s and 1960s, IgG, IgM, IgA, and IgD were sequentially
discovered. By the end of 1964, most immunologists and
allergists believed that reagin is an allergen-specific IgA antibody.
Eventually, in 1966, Ishizaka et al. discovered the immunoglobulin
responsible for allergy—IgE, named after the erythema-wheal.
IgE was the last immunoglobulin discovered due